Endocrine Abstracts

Obesity is a major cause of chronic hypoventilation and/or obstructive sleep apnea syndrome (OSAS). Aim of this study was to evaluate the prevalence of pulmonary dysfunction and the relationship between OSAS and several clinical, functional and polysomnographics parameters in severely obese patients. 101 subjects (68 females and 33 males) aged 49.2±13.2 years (mean±S.D.), with BMI 46.8±6.5 Kg/m2 were enrolled. Sleep quality and daytime ...

Introduction: As an alternative to cortisol assays in the serum or saliva to diagnose hypercorticisme we evaluated the ability of a commercial cortisol assay to assess capillary blood cortisol concentrations using routine procedures.Methods: Capillary blood was obtained using a device used by diabetics to routinely assess capillary glucose levels and deposited on Schleicher-Scheull 903 blotter paper (routinely used for neonatal diagnosis of hypothyroidis...

IntroductionDeQuervain’s subacute thyroiditis (DST) is a rare pathology, defined by the involvement of the thyroid gland by an inflammatory process probably of viral origin, not suppurative and not autoimmune. In this context, we report 4 cases of TSD followed up in the endocrinology department over a period of 23 years, to highlight diagnostic and therapeutic particularities.ResultsThe average age was 3...

Objective: Despite combination with peripheral decarboxylase inhibitors significant amounts of L-dopa are peripherally metabolised. In patients with Parkinson’s disease (PD) treated with L-dopa and a dopa decarboxylase inhibitor, urinary dopamine concentrations are markedly elevated. We describe here a L-dopa treated PD patient presenting with a clinical and biochemical picture suspicious of phaeochromocytoma.Case report: A 73-year-old female patien...

Sweet syndrome is a febrile dermatosis characterized by painful light red patches of quite different size involving various skin zones associated with flu like symptoms, arthralgias and rarely frank arthritis. Originally considered rare, over 500 cases in the past 10 years have been described. The etiology of Sweet’s syndrome is unknown, but a type of hypersensitivity reaction leading to stimulation of a cascade of cytokines has been strongly suggested. In very few cases ...

Introduction: Klinefelter`s syndrome is a chromosomal abnormality characterised by presence of one or more extra X chromosome(s). The commonest karyotype is 47 XXY. We report a case of craniopharyngioma in a patient with Klinefelter`s syndrome.Case report: A 72-year-old single male presented with three-month history of decreased left eye visual acuity with associated frontal headache and lethargy. His past medical history included osteoporosis and Klinef...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused a global pandemic in 2020. The virus has infected more than 100 million people worldwide and the pandemic is still spreading. It can affect practically all organs. Data on the impact of SARSCoV-2 on the thyroid gland are very scarce. Two patients with Graves’ disease (GD) and COVID-19 have been recently published(1). We present a case GD occur...

Purpose: To determine the prevalence of nodular thyroid disease, autoimmune thyroid disease, goiter and primary thyroid dysfunction in patients with active Cushing’s disease.Patients and methods: Nineteen patients with active Cushing’s disease (17 female, 2 male, mean age 43.16±3.55 years) and forty, age and gender matched healthy volunteers who served as the control group (34 female, 6 male, mean age 47.28±2.31 years) were included i...

Introduction: Central Serous Retinopathy (CSR) is a condition characterized by the accumulation of sub-retinal fluid at the posterior pole of the fundus, creating a circumscribed area of serous retinal detachment. It is associated with increased levels of endogenous or exogenous glucocorticoids and has been described in patients with Cushing’s syndrome (CS).Here we report on two cases we recently managed in our unit, with central serous retinopathy ...

Objective: Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk of the early atherosclerosis. The aim of this study was to compare levels of s-ICAM-1 and s-VCAM-1 in asymptomatic members of FCH families with healthy controls and to find out relation between s-ICAM-1, respective s-VCAM-1, and risk factors accompanying FCH. We also investigate association between adhesion molecules and intima-media thickness of common carotid artery ...